Design, synthesis and antiviral potential of 14-aryl/heteroaryl-14H-dibenzo[a,j]xanthenes using an efficient polymer-supported catalyst

Molecules. 2012 Jun 18;17(6):7543-55. doi: 10.3390/molecules17067543.

Abstract

Polyethyleneglycol bound sulfonic acid (PEG-OSO₃H), a chlorosulphonic acid-modified polyethylene glycol was successfully used as an efficient and eco-friendly polymeric catalyst in the synthesis of 14-aryl/heteroaryl-14H-dibenzo[a,j]xanthenes obtained from the reaction of 2-naphthol and carbonyl compounds under solvent-free conditions with short reaction times and excellent yields. The biological properties of these synthesized title compounds revealed that compounds 3b, 3c, 3f and 3i showed highly significant anti-viral activity against tobacco mosaic virus.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aldehydes / chemistry
  • Antiviral Agents / chemical synthesis*
  • Antiviral Agents / chemistry
  • Antiviral Agents / pharmacology*
  • Catalysis
  • Naphthols / chemistry
  • Polyethylene Glycols / chemistry
  • Polymers / chemistry*
  • Temperature
  • Tobacco Mosaic Virus / drug effects
  • Xanthenes / chemical synthesis*
  • Xanthenes / chemistry
  • Xanthenes / pharmacology*

Substances

  • Aldehydes
  • Antiviral Agents
  • Naphthols
  • Polymers
  • Xanthenes
  • Polyethylene Glycols
  • 2-naphthol