Efficient palladium-catalyzed synthesis of substituted indoles employing a new (silanyloxyphenyl)phosphine ligand

Chem Commun (Camb). 2012 Jul 25;48(58):7277-9. doi: 10.1039/c2cc33071g. Epub 2012 Jun 18.

Abstract

The new and easily prepared OTips-DalPhos ligand (L1) offers broad substrate scope at relatively low loadings in the palladium-catalyzed C-N cross-coupling/cyclization of o-alkynylhalo(hetero)arenes with primary amines, affording indoles and related heterocyclic derivatives in high yield.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amines / chemistry
  • Catalysis
  • Cyclization
  • Indoles / chemical synthesis*
  • Indoles / chemistry
  • Ligands
  • Molecular Conformation
  • Palladium / chemistry*
  • Phosphines / chemical synthesis*
  • Phosphines / chemistry
  • Silanes / chemical synthesis*
  • Silanes / chemistry

Substances

  • Amines
  • Indoles
  • Ligands
  • Phosphines
  • Silanes
  • Palladium