Abstract
Water-soluble, PAX-loaded carbon nanotubes are fabricated by employing a synthetic polyampholyte, PDM. To investigate the suitability of the polyampholyte and the nanotubes as drug carriers, different cellular interactions such as the human epithelial Caco-2 cells viability, their effect on the cell growth, and the change in the transepithelial electrical resistance in Caco-2 cells are studied. The resulting complex is found to exhibit an effective anti-cancer effect against colon cancer cells and an increased the reduction of the electrical resistance in the Caco-2 cells when compared to the precursor PAX.
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents, Phytogenic / chemistry
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Antineoplastic Agents, Phytogenic / pharmacology*
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Buffers
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Caco-2 Cells
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Cell Survival / drug effects
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Delayed-Action Preparations / chemistry*
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Delayed-Action Preparations / pharmacology
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Drug Carriers / chemical synthesis*
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Drug Carriers / pharmacology
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Drug Compounding
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Electric Impedance
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Humans
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Methacrylates / chemistry
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Microscopy, Electron, Scanning
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Nanotubes, Carbon / chemistry*
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Nanotubes, Carbon / ultrastructure
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Paclitaxel / chemistry
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Paclitaxel / pharmacology*
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Polymerization
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Rhodamine 123
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Solubility
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Water
Substances
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Antineoplastic Agents, Phytogenic
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Buffers
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Delayed-Action Preparations
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Drug Carriers
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Methacrylates
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Nanotubes, Carbon
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Water
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methacrylic acid
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Rhodamine 123
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2-(dimethylamino)ethyl methacrylate
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Paclitaxel