In a patient with rhabdomyolysis-associated anuric acute kidney injury, an 8-hour haemodialysis session was performed with a large-pore, high cut-off (HCO) membrane (in-vivo cutoff, 60 kDa). Subsequently, during another 8-hour dialysis session, a standard high-flux (HF) membrane (in-vivo cut-off, 15kDa) was used. Serum myoglobin levels were measured throughout both sessions. HCO haemodialysis reduced myoglobin serum levels by 50% within 4 hours (from 44946μg/L to 22315μg/L). In contrast, myoglobin serum levels increased from 21430μg/L to 34336μg/L during HF haemodialysis. Thus, HCO haemodialysis achieved a reduction in serum myoglobin level that is superior to any other renal replacement technique so far.