Influenza virus A(H5N1), since its first appearance in Hong Kong in 1997 killing six people, has continuously recorder by 2003 both new cases and deaths between these. Although the media and social attention received in the years between 2006 and 2008, mainly in Italy is not currently present, the same is not true for the avian flu that still exists in some countries. At the regulatory level, at the beginning of 2006 the Ministry of Health indicated the measures to be taken in the national preparedness and response to a pandemic flu, and the national Legislative Decree 25 January 2010, n. 9 makes implementing the EU Directive 2005/94/CE on Community measures to combat avian flu. Moreover, an article published in June 2010 show a new route of transmission of avian viruses by birds. The topic on avian flu, especially aimed at the protection of workers potentially exposed, has been long the subject of studies, and in particular for operators belonging to the Corpo Nazionale dei Vigili del Fuoco (C.N.VV.F.). In particular, in the context of the measures taken to address any outbreak of avian flu, were carried out one manual addressed to operators by C.N.VV.F. and to so-called managers/operators of the emergency public service workers represented by the operators of the C.N.VVF. and of Police, Civil Protection, and Voluntary Organisations of rescue enclosed in Civil Protection Service. It is necessary to reiterate the importance of continued and growing of the preparation and information for workers, brought to the operators themselves useful about the adoption of preventive and protective measures by the workers belonging to groups at risk of potential exposure to avian influenza viruses.