Tumor-homing poly-siRNA/glycol chitosan self-cross-linked nanoparticles for systemic siRNA delivery in cancer treatment

Angew Chem Int Ed Engl. 2012 Jul 16;51(29):7203-7. doi: 10.1002/anie.201201390. Epub 2012 Jun 13.

Abstract

The condensed version: Thiolated glycol chitosan can form stable nanoparticles with polymerized siRNAs through charge-charge interactions and self-cross-linking (see scheme). This poly-siRNA/glycol chitosan nanoparticles (psi-TGC) provided sufficient in vivo stability for systemic delivery of siRNAs. Knockdown of tumor proteins by psi-TGC resulted in a reduction in tumor size and vascularization.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cell Line, Tumor
  • Chitosan / chemistry*
  • Genetic Therapy
  • Humans
  • Mice
  • Nanoparticles / chemistry*
  • Neoplasms / genetics
  • Neoplasms / pathology
  • Neoplasms / therapy*
  • RNA Interference*
  • RNA, Small Interfering / administration & dosage*
  • RNA, Small Interfering / genetics
  • RNA, Small Interfering / therapeutic use*
  • Sulfhydryl Compounds / chemistry
  • Vascular Endothelial Growth Factor A / genetics

Substances

  • RNA, Small Interfering
  • Sulfhydryl Compounds
  • Vascular Endothelial Growth Factor A
  • glycol-chitosan
  • Chitosan