The purpose of the study was to compare the mechanical impact and the corresponding physiological responses of 4 different and often practically applied resistance training methods (RTMs). Ten healthy male subjects (27.3 ± 3.2 years) experienced in resistance training performed 1 exhausting set of bench press exercise until exhaustion for each of the following RTMs: strength endurance (SE), fast force endurance (FFE), hypertrophy (HYP), and maximum strength (MAX). The RTMs were defined by different lifting masses and different temporal distributions of the contraction modes per repetition. Mean concentric power (P), total concentric work (W), and exercise time (EXTIME) were determined. Oxygen uptake (V[Combining Dot Above]O2) was measured during exercise and for 30 minutes postexercise. Mean V[Combining Dot Above]O2, volume of consumed O2, and excess postexercise oxygen consumption (EPOC) were calculated over 30 minutes of recovery. Maximum blood lactate concentration (LAmax) was also determined postexercise. The P was significantly higher (p < 0.01) for FFE and MAX compared with that for SE and HYP. The W was significantly higher for FFE than for all other RTMs (p < 0.01), and it was also lower for SE than for MAX (p < 0.05). EXTIME for SE was significantly higher (p < 0.01) than for all other RTMs, whereas EXTIME for MAX was significantly lower (p < 0.01) than for all other RTMs. Mean V[Combining Dot Above]O2 was significantly higher during FFE than during all other RTMs (p < 0.01). Consumed O2 was significantly higher (p < 0.05) during SE than for HYP and MAX, and it was also significantly higher for FFE and HYP compared with MAX (p < 0.05). The LAmax was significantly higher after FFE than after MAX (p < 0.05). There were no significant differences in EPOC between all RTMs. The results indicate that FFE and MAX are adequate to train muscular power despite the discrepancy in the external load. Because FFE performance achieves the highest amount in mechanical work, it may also elicit the highest total energy expenditure. The FFE challenges aerobic metabolism most and SE enables the longest EXTIME, indicating both are appropriate to enhance aerobic muscular capacities. The EPOC and LA values may indicate that energy needs covered by anaerobic metabolism are not higher during HYP and MAX compared with the RTM of lower external load.