Cardiovascular properties of a nitric oxide releasing rofecoxib analogue: beneficial anti-hypertensive activity and enhanced recovery in an ischemic reperfusion injury model

ChemMedChem. 2012 Aug;7(8):1365-8. doi: 10.1002/cmdc.201200234. Epub 2012 Jun 11.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antihypertensive Agents / chemistry
  • Antihypertensive Agents / pharmacology
  • Antihypertensive Agents / therapeutic use*
  • Blood Pressure / drug effects
  • Cyclooxygenase 2 / chemistry
  • Cyclooxygenase 2 / metabolism
  • Disease Models, Animal
  • Drug Design
  • Female
  • Heart Rate / drug effects
  • Lactones / chemistry
  • Lactones / pharmacology
  • Lactones / therapeutic use*
  • Mice
  • Mice, Inbred C57BL
  • Nitric Oxide / metabolism*
  • Nitric Oxide Donors / chemistry
  • Nitric Oxide Donors / pharmacology
  • Nitric Oxide Donors / therapeutic use
  • Reperfusion Injury / drug therapy*
  • Sulfones / chemistry
  • Sulfones / pharmacology
  • Sulfones / therapeutic use*

Substances

  • Antihypertensive Agents
  • Lactones
  • Nitric Oxide Donors
  • Sulfones
  • rofecoxib
  • Nitric Oxide
  • Cyclooxygenase 2