Core-shell nanocapsules stabilized by single-component polymer and nanoparticles for magneto-chemotherapy/hyperthermia with multiple drugs

Shang-Hsiu Hu; Bang-Jie Liao; Chin-Sheng Chiang; Po-Jung Chen; I-Wei Chen; San-Yuan Chen

doi:10.1002/adma.201201251

Core-shell nanocapsules stabilized by single-component polymer and nanoparticles for magneto-chemotherapy/hyperthermia with multiple drugs

Adv Mater. 2012 Jul 17;24(27):3627-32. doi: 10.1002/adma.201201251. Epub 2012 Jun 12.

Authors

Shang-Hsiu Hu¹, Bang-Jie Liao, Chin-Sheng Chiang, Po-Jung Chen, I-Wei Chen, San-Yuan Chen

Affiliation

¹ Department of Materials Science and Engineering, National Chiao Tung University, Hsinchu 300, Taiwan.

PMID: 22689346
DOI: 10.1002/adma.201201251

Abstract

Iron-oxide-containing double emulsion capsules carrying both hydrophilic and hydrophobic therapeutic molecules can deliver drugs and energy on demand in vivo. Magneto-chemotherapy/hyperthermia involves a burst-like release of hydrophilic doxorubicin and hydrophobic paclitaxel, remotely triggered by a high frequency magnetic field, which also releases energy via internalized iron oxide nanoparticles, all contributing to cell kill.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Antineoplastic Agents / administration & dosage*
Cell Line, Tumor
Doxorubicin / administration & dosage
Emulsions / chemistry
Ferric Compounds / chemistry
HeLa Cells
Humans
Hydrophobic and Hydrophilic Interactions
Hyperthermia, Induced
Magnetic Fields
Mice
Nanocapsules / chemistry*
Nanoparticles / chemistry*
Neoplasms / drug therapy*
Paclitaxel / administration & dosage
Polymers / chemistry*
Transplantation, Heterologous

Substances

Antineoplastic Agents
Emulsions
Ferric Compounds
Nanocapsules
Polymers
ferric oxide
Doxorubicin
Paclitaxel