Orthotopic liver transplantation is the only definitive treatment option for patients dying of liver failure. Since its inception, the technique of liver transplantation and the management of the recipients have evolved considerably. The authors present here an up-to-date overview of the evolution of adult liver transplantation, the evaluation of the recipient and the process of listing and timing of transplantation. The authors conclude with a summary of long-term complications that should be considered when caring for the posttransplant patient. The growing population of patients with liver disease means that more transplants will be performed. Because these patients now live longer lives, it is crucial that clinicians have a basic understanding of the process and outcomes.