Combinatorial solid-phase synthesis of 4,6-diaryl and 4-aryl, 6-alkyl-1,3,5-triazines and their application to efficient biofuel production

ACS Comb Sci. 2012 Jul 9;14(7):395-8. doi: 10.1021/co300007a. Epub 2012 Jun 12.

Abstract

Herein we report the solid-phase synthesis of a combinatorial aryl, alkyl-triazine library and its application to biofuel production. The combination of Grignard reactions and solid supported Suzuki coupling reactions afforded unique 120 triazine compounds with high purities and minimum purification steps. Through an unbiased phenotypic screening for improved biofuel generation in oleaginous yeast, we found one diaryl triazine derivative (E4) which increased the biolipid production up to 86%.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Biofuels* / analysis
  • Biofuels* / microbiology
  • Combinatorial Chemistry Techniques / methods
  • Small Molecule Libraries / chemical synthesis*
  • Small Molecule Libraries / chemistry
  • Solid-Phase Synthesis Techniques / methods*
  • Triazines / chemical synthesis*
  • Triazines / chemistry

Substances

  • Biofuels
  • Small Molecule Libraries
  • Triazines