Recent progress in interfacial tissue engineering approaches for osteochondral defects

Nathan J Castro; S Adam Hacking; Lijie Grace Zhang

doi:10.1007/s10439-012-0605-5

Recent progress in interfacial tissue engineering approaches for osteochondral defects

Ann Biomed Eng. 2012 Aug;40(8):1628-40. doi: 10.1007/s10439-012-0605-5. Epub 2012 Jun 8.

Authors

Nathan J Castro¹, S Adam Hacking, Lijie Grace Zhang

Affiliation

¹ Department of Mechanical and Aerospace Engineering, Institute for Biomedical Engineering and Institute for Nanotechnology, The George Washington University, 726 Phillips Hall, 801 22nd Street NW, Washington, DC 20052, USA.

PMID: 22677924
DOI: 10.1007/s10439-012-0605-5

Abstract

This review provides a brief synopsis of the anatomy and physiology of the osteochondral interface, scaffold-based and non-scaffold based approaches for engineering both tissues independently as well as recent developments in the manufacture of gradient constructs. Novel manufacturing techniques and nanotechnology will be discussed with potential application in osteochondral interfacial tissue engineering.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Bone Diseases / therapy*
Cartilage Diseases / therapy*
Humans
Nanotechnology / methods*
Nanotechnology / trends
Tissue Engineering / methods*
Tissue Engineering / trends