Hemostasis of patients with III stage malignant neoplasms of the maxilla and larynx was investigated. We examined 40 patients, 8 of which had maxillary tumor and 32 had laryngeal tumor. The age of the patients varied from 44 to 68 years. It was found that the patients with malignant neoplasms of the maxilla and larynx had hemostatic disorders which formed the thrombohemorrhagic syndrome. During the surgical intervention they displayed the hypocoagulation phase of the syndrome, which indicated the most dangerous prethrombotic state of the blood system.