Aggressive coronary artery vasculopathy after combined heart-lung transplantation

Congenit Heart Dis. 2013 May-Jun;8(3):E88-91. doi: 10.1111/j.1747-0803.2012.00681.x. Epub 2012 Jun 8.

Abstract

Combined heart-lung transplantation remains as a treatment option for patients with cardiopulmonary failure. There is speculation that lung grafts protect the heart from developing graft vasculopathy after combined heart-lung transplantation. This protective mechanism is more likely, at best, a delay in the onset of coronary artery vasculopathy. We present our experiences in two cases of an aggressive form of cardiac allograft vasculopathy after combined heart-lung transplantation that resulted in the death of both patients.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Biopsy
  • Bronchiolitis Obliterans / etiology
  • Cardiovascular Agents / therapeutic use
  • Coronary Angiography
  • Coronary Artery Disease / diagnosis
  • Coronary Artery Disease / drug therapy
  • Coronary Artery Disease / etiology*
  • Fatal Outcome
  • Female
  • Graft Rejection / drug therapy
  • Graft Rejection / etiology
  • Heart Defects, Congenital / surgery*
  • Heart-Lung Transplantation / adverse effects*
  • Humans
  • Immunosuppressive Agents / therapeutic use
  • Treatment Outcome
  • Young Adult

Substances

  • Cardiovascular Agents
  • Immunosuppressive Agents