Abstract
The authors describe a patient treated with amiodarone presented with high low-density lipoprotein cholesterol (LDL-C) levels who did not respond to treatment with a statin. Both amiodarone and amiodarone induced hypothyroidism influence the synthesis of LDL-receptor which may explain the lack of effect of statin. This was confirmed by normalisation of LDL-C upon discontinuation of amiodarone and treatment with thyroxine.
MeSH terms
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Adult
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Amiodarone / adverse effects
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Anti-Arrhythmia Agents / adverse effects
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Cholesterol, LDL / blood
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Drug Resistance*
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Fluorobenzenes / therapeutic use
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Humans
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Hydroxymethylglutaryl-CoA Reductase Inhibitors / therapeutic use
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Hypercholesterolemia / blood
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Hypercholesterolemia / drug therapy*
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Hypercholesterolemia / etiology*
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Hypothyroidism / chemically induced
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Hypothyroidism / complications*
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Hypothyroidism / drug therapy
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Male
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Pyrimidines / therapeutic use
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Rosuvastatin Calcium
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Sulfonamides / therapeutic use
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Thyroxine / therapeutic use
Substances
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Anti-Arrhythmia Agents
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Cholesterol, LDL
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Fluorobenzenes
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Hydroxymethylglutaryl-CoA Reductase Inhibitors
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Pyrimidines
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Sulfonamides
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Rosuvastatin Calcium
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Amiodarone
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Thyroxine