Statin resistant dyslipidemia in a patient treated with amiodarone

BMJ Case Rep. 2011 Oct 11:2011:bcr0820114620. doi: 10.1136/bcr.08.2011.4620.

Abstract

The authors describe a patient treated with amiodarone presented with high low-density lipoprotein cholesterol (LDL-C) levels who did not respond to treatment with a statin. Both amiodarone and amiodarone induced hypothyroidism influence the synthesis of LDL-receptor which may explain the lack of effect of statin. This was confirmed by normalisation of LDL-C upon discontinuation of amiodarone and treatment with thyroxine.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Amiodarone / adverse effects
  • Anti-Arrhythmia Agents / adverse effects
  • Cholesterol, LDL / blood
  • Drug Resistance*
  • Fluorobenzenes / therapeutic use
  • Humans
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors / therapeutic use
  • Hypercholesterolemia / blood
  • Hypercholesterolemia / drug therapy*
  • Hypercholesterolemia / etiology*
  • Hypothyroidism / chemically induced
  • Hypothyroidism / complications*
  • Hypothyroidism / drug therapy
  • Male
  • Pyrimidines / therapeutic use
  • Rosuvastatin Calcium
  • Sulfonamides / therapeutic use
  • Thyroxine / therapeutic use

Substances

  • Anti-Arrhythmia Agents
  • Cholesterol, LDL
  • Fluorobenzenes
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors
  • Pyrimidines
  • Sulfonamides
  • Rosuvastatin Calcium
  • Amiodarone
  • Thyroxine