Continuous synthesis and purification by direct coupling of a flow reactor with simulated moving-bed chromatography

Alexander G O'Brien; Zoltán Horváth; François Lévesque; Ju Weon Lee; Andreas Seidel-Morgenstern; Peter H Seeberger

doi:10.1002/anie.201202795

Continuous synthesis and purification by direct coupling of a flow reactor with simulated moving-bed chromatography

Angew Chem Int Ed Engl. 2012 Jul 9;51(28):7028-30. doi: 10.1002/anie.201202795. Epub 2012 Jun 6.

Authors

Alexander G O'Brien¹, Zoltán Horváth, François Lévesque, Ju Weon Lee, Andreas Seidel-Morgenstern, Peter H Seeberger

Affiliation

¹ Department for Biomolecular Systems, Max-Planck Institute for Colloids and Interfaces, Potsdam, Germany.

PMID: 22674846
DOI: 10.1002/anie.201202795

Abstract

Continuous synthesis meets continuous purification to produce pure products from crude reaction mixtures. In the nucleophilic aromatic substitution of 2,4-difluoronitrobenzene with morpholine the desired monosubstituted product can be continuously separated from the byproducts in a purity of over 99 % by coupling a flow reactor to a simulated moving bed (SMB) chromatography module.