Imaging features of bowel toxicities in the setting of molecular targeted therapies in cancer patients

Br J Radiol. 2012 Oct;85(1018):1420-6. doi: 10.1259/bjr/19815818. Epub 2012 Jun 6.

Abstract

Molecular targeted therapies are becoming ubiquitous in cancer treatment. These drugs may cause gastrointestinal toxicities including perforation, pneumatosis, enteritis, colitis and fistula formation. Knowledge of these complications and their management enables early radiological identification and appropriate intervention, reducing patient morbidity and mortality.

MeSH terms

  • Aged
  • Colitis / diagnostic imaging
  • Colitis / etiology
  • Female
  • Gastroenteritis / diagnostic imaging
  • Gastroenteritis / etiology
  • Humans
  • Intestinal Diseases / diagnostic imaging
  • Intestinal Diseases / etiology*
  • Intestinal Fistula / diagnostic imaging
  • Intestinal Fistula / etiology
  • Intestinal Perforation / diagnostic imaging
  • Intestinal Perforation / etiology
  • Male
  • Middle Aged
  • Molecular Targeted Therapy / adverse effects*
  • Neoplasms / therapy*
  • Pneumatosis Cystoides Intestinalis / diagnostic imaging
  • Pneumatosis Cystoides Intestinalis / etiology
  • Tomography, X-Ray Computed