Abstract
Purpose:
To report 5 cases of culture-proven fungal keratitis that resolved with moxifloxacin monotherapy.
Methods:
Case reports and review of medical literature. Five patients with fungal keratitis were treated with topical moxifloxacin.
Results:
All 5 patients had resolution of their infection with topical moxifloxacin monotherapy.
Conclusions:
Topical fluoroquinolone agents may have significant antifungal properties. However, the vast majority of fungal keratitis patients cannot be cured with fluoroquinolone monotherapy. An initial response of keratitis to topical fluoroquinolone therapy should not lead to the assumption that the infection is bacterial because the possibility of fungal infection cannot be ruled out on that basis.
Publication types
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Case Reports
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Aged
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Anti-Infective Agents / therapeutic use*
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Ascomycota / isolation & purification
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Aspergillus / isolation & purification
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Aza Compounds / therapeutic use*
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Candida / isolation & purification
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Corneal Ulcer / drug therapy*
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Corneal Ulcer / microbiology
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Eye Infections, Fungal / drug therapy*
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Eye Infections, Fungal / microbiology
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Female
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Fluoroquinolones
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Humans
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Male
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Middle Aged
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Moxifloxacin
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Mycoses / drug therapy*
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Mycoses / microbiology
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Paecilomyces / isolation & purification
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Quinolines / therapeutic use*
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Treatment Outcome
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Visual Acuity / physiology
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Young Adult
Substances
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Anti-Infective Agents
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Aza Compounds
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Fluoroquinolones
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Quinolines
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Moxifloxacin