Gold-catalyzed cycloisomerization of 1,7-diyne benzoates to indeno[1,2-c]azepines and azabicyclo[4.2.0]octa-1(8),5-dines

Weidong Rao; Ming Joo Koh; Prasath Kothandaraman; Philip Wai Hong Chan

doi:10.1021/ja304964s

Gold-catalyzed cycloisomerization of 1,7-diyne benzoates to indeno[1,2-c]azepines and azabicyclo[4.2.0]octa-1(8),5-dines

J Am Chem Soc. 2012 Jul 4;134(26):10811-4. doi: 10.1021/ja304964s. Epub 2012 Jun 25.

Authors

Weidong Rao¹, Ming Joo Koh, Prasath Kothandaraman, Philip Wai Hong Chan

Affiliation

¹ Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore 637371, Singapore.

PMID: 22663059
DOI: 10.1021/ja304964s

Abstract

A synthetic method that relies on Au(I)-catalyzed cycloisomerization reactions of 1,7-diyne benzoates to prepare indeno[1,2-c]azepines and azabicyclo[4.2.0]octa-1(8),5-dines is described.