CuI/DMPAO-catalyzed N-arylation of acyclic secondary amines

Org Lett. 2012 Jun 15;14(12):3056-9. doi: 10.1021/ol301135c. Epub 2012 Jun 4.

Abstract

DMPAO has been found to be a powerful ligand to enable copper-catalyzed coupling of aryl halides with aliphatic acyclic secondary amines take place under relatively mild conditions, and coupling of aryl halides with primary amines and cyclic secondary amines proceeds at low catalyst loading.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amines / chemistry*
  • Aniline Compounds / chemistry*
  • Catalysis
  • Copper / chemistry*
  • Iodides / chemistry*
  • Ligands
  • Molecular Structure

Substances

  • 2-(2,6-dimethylphenylamino)-2-oxoacetic acid
  • Amines
  • Aniline Compounds
  • Iodides
  • Ligands
  • Copper
  • cuprous iodide