Improving drug delivery to pancreatic cancer: breaching the stromal fortress by targeting hyaluronic acid

MeSH terms

• Animals
• Antimetabolites, Antineoplastic / administration & dosage*
• Antimetabolites, Antineoplastic / therapeutic use
• Biomarkers, Tumor / metabolism*
• Cell Adhesion Molecules / administration & dosage
• Cell Adhesion Molecules / pharmacology
• Deoxycytidine / administration & dosage
• Deoxycytidine / analogs & derivatives*
• Deoxycytidine / therapeutic use
• Drug Delivery Systems*
• Drug Resistance, Neoplasm* / drug effects
• Drug Resistance, Neoplasm* / physiology
• Gemcitabine
• Humans
• Hyaluronic Acid / metabolism*
• Hyaluronoglucosaminidase / administration & dosage
• Hyaluronoglucosaminidase / pharmacology
• Mice
• Pancreatic Neoplasms / drug therapy*
• Pancreatic Neoplasms / metabolism
• Recombinant Proteins / administration & dosage
• Recombinant Proteins / pharmacology