Abstract
Inflammatory bowel diseases (IBD) including Crohn's disease (CD) and ulcerative colitis (UC) have a major impact on the health of individuals and populations. These diseases result from an inappropriate immune response, in genetically susceptible individuals, to microbial antigens of commensal microorganisms. This paper reviews the abnormal bone metabolism associated with CD, in order to elucidate the mechanism of bone loss.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Adrenal Cortex Hormones / adverse effects
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Antibodies, Monoclonal / therapeutic use
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Bone Diseases, Metabolic / etiology
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Bone Diseases, Metabolic / metabolism
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Bone Diseases, Metabolic / therapy
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Bone Remodeling / drug effects
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Bone and Bones / drug effects
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Bone and Bones / metabolism*
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Calcium / deficiency
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Calcium / metabolism
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Crohn Disease / complications
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Crohn Disease / drug therapy
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Crohn Disease / metabolism*
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Female
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Humans
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Infliximab
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Male
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Models, Biological
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Risk Factors
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Tumor Necrosis Factor-alpha / antagonists & inhibitors
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Vitamin D / metabolism
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Vitamin D Deficiency / complications
Substances
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Adrenal Cortex Hormones
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Antibodies, Monoclonal
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Tumor Necrosis Factor-alpha
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Vitamin D
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Infliximab
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Calcium