Abstract
Six β-carboline alkaloids (1-6) of the eudistomin Y class were isolated from the Korean ascidian Synoicum sp. These compounds were chemically converted to a known compound, eudistomin Y(1) (7) and six new derivatives, designated eudistomins Y(8)-Y(13) (8-13). Several of these natural and synthetic compounds exhibited moderate to significant antimicrobial activity, weak cytotoxic activity, and inhibitory activities toward sortase A, isocitrate lyase, and Na(+)/K(+)-ATPase. Structure-activity relationships were also deduced.
Copyright © 2012 Elsevier Ltd. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alkaloids / chemistry*
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Alkaloids / pharmacology
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Alkaloids / toxicity
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Aminoacyltransferases / antagonists & inhibitors
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Aminoacyltransferases / metabolism
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Animals
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Anti-Infective Agents / chemistry*
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Anti-Infective Agents / pharmacology
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Anti-Infective Agents / toxicity
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Bacterial Proteins / antagonists & inhibitors
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Bacterial Proteins / metabolism
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Carbolines / chemical synthesis
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Carbolines / chemistry*
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Cell Line, Tumor
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Cell Survival / drug effects
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Cysteine Endopeptidases / metabolism
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Gram-Negative Bacteria / drug effects
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Gram-Positive Bacteria / drug effects
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Humans
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Isocitrate Lyase / antagonists & inhibitors
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Isocitrate Lyase / metabolism
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Sodium-Potassium-Exchanging ATPase / antagonists & inhibitors
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Sodium-Potassium-Exchanging ATPase / metabolism
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Structure-Activity Relationship
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Urochordata / chemistry*
Substances
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Alkaloids
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Anti-Infective Agents
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Bacterial Proteins
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Carbolines
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Aminoacyltransferases
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sortase A
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Cysteine Endopeptidases
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Isocitrate Lyase
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Sodium-Potassium-Exchanging ATPase