Design, synthesis, and spectroscopic properties of extended and fused pyrrolo-dC and pyrrolo-C analogs

Org Lett. 2012 Jun 15;14(12):3150-3. doi: 10.1021/ol3012327. Epub 2012 May 30.

Abstract

The syntheses of four fluorescent nucleoside analogs, related to pyrrolo-C (PyC) and pyrrolo-dC (PydC) through the conjugation or fusion of a thiophene moiety, are described. A thorough photophysical analysis of the nucleosides, in comparison to PyC, is reported.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Cytidine / analogs & derivatives*
  • Cytidine / chemistry
  • Fluorescent Dyes / chemical synthesis*
  • Hydrogen Bonding
  • Molecular Structure
  • Pyrroles / chemistry*
  • Spectrum Analysis
  • Thiophenes / chemistry

Substances

  • Fluorescent Dyes
  • Pyrroles
  • Thiophenes
  • pyrrolo-C
  • Cytidine