The article presents our experience with using antiadhesive means "Seprafilm", "Interceed" and "Adept" in patients with abdominal adhesive disease. "Seprafilm" was applied in 18 patients, among them 13 underwent laparoscopic and 5 open adhesiolysis. Liquid antiadhesive barrier "Adept" was used in 53 patients (in 33--laparoscopically and in 20--by laparotomy). "Interceed" mesh was used in 16 patients in open adhesiolysis. The combination of laparoscopy and antiadhesive barrier allows receiving good results by minimization of the operative trauma and influencing the process of adhesion formation. During laparoscopic interventions the application of liquid antiadhesive means is technically more convenient.