Tuberculosis is one of the leading causes of infectious disease worldwide, with an estimate of more than 8 million new cases each year. Tuberculosis notification rates have been decreasing since 2002, but some countries, in Asia and sub-Saharan Africa, are still particularly affected. HIV co-infection and the emergence of resistant strains warrant further efforts to improve tuberculosis control worldwide. France is considered as a low incidence country but important disparities between populations and territories exist. Thus, the elderly, those living in large cities or in socio-economic deprived condition and persons born in high-endemic countries are mostly affected. The national tuberculosis program was launched in 2007, aiming at reducing these disparities.