MicroRNA factory: RISC assembly from precursor microRNAs

Yoosik Kim; V Narry Kim

doi:10.1016/j.molcel.2012.05.012

MicroRNA factory: RISC assembly from precursor microRNAs

Mol Cell. 2012 May 25;46(4):384-6. doi: 10.1016/j.molcel.2012.05.012.

Authors

Yoosik Kim¹, V Narry Kim

Affiliation

¹ School of Biological Sciences, Seoul National University, Seoul, Korea.

PMID: 22633486
DOI: 10.1016/j.molcel.2012.05.012

Abstract

RNA silencing requires assembly of an effector complex, RNA-induced silencing complex (RISC), composed of a small RNA and the Ago protein. In this issue of Molecular Cell, Liu et al. (2012) provide insights of miRNP/RISC assembly pathways in mammals, using an in vitro human RISC assembly assay programmed by pre-miRNAs.

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