Context: Heme oxygenase-1 (HO-1) is implicated to be correlated with renal function in oxidative stress.
Objective: To determine whether urinary (u) HO-1 is associated with the progression of congenital obstructive hydronephrosis (HN).
Methods: A total 50 children with HN (study group and control 1) and 30 healthy children were enrolled in this study.
Results: The uHO-1/cr levels increased significantly and negatively correlated with split renal function in study group before and during surgery. One month after surgery, it decreased significantly.
Conclusion: Increased uHO-1 levels could be a potential biomarker for evaluating the progression of obstructive nephropathy.