[Cultured cell systems for revelation of new drugs antiatherosclerotic effects and their mechanisms investigation]

A N Orekhov; I A Sobenin; V A Orekhova; A A Mel'nichenko; V A Miasoedova; N M Mukhamedova; D M Martirosian; A V Pshezhetskiĭ; V P Karagodin

[Cultured cell systems for revelation of new drugs antiatherosclerotic effects and their mechanisms investigation]

Patol Fiziol Eksp Ter. 2012 Jan-Mar:(1):33-9.

[Article in Russian]

Authors

A N Orekhov, I A Sobenin, V A Orekhova, A A Mel'nichenko, V A Miasoedova, N M Mukhamedova, D M Martirosian, A V Pshezhetskiĭ, V P Karagodin

PMID: 22629858

Abstract

Cultured cell models have been developed to study the cholesterol efflux from the arterial wall as an integral indicator of reverse cholesterol transport. The models and the results of in vivo and ex vivo experiments can be used to propose new antiatherosclerotic drugs and elucidate their mood of action.

Publication types

English Abstract
Research Support, Non-U.S. Gov't

MeSH terms

Adult
Anticholesteremic Agents / chemistry
Anticholesteremic Agents / pharmacology*
Arteries / metabolism*
Arteries / pathology
Atherosclerosis / drug therapy*
Atherosclerosis / metabolism
Atherosclerosis / pathology
Cells, Cultured
Cholesterol / metabolism*
Drug Evaluation, Preclinical / methods
Female
Humans
Male
Middle Aged
Models, Biological*

Substances

Anticholesteremic Agents
Cholesterol