[Muscle relaxants and neuromuscular monitoring - Introduction for a safe clinical application]

Anasthesiol Intensivmed Notfallmed Schmerzther. 2012 May;47(5):296-305; quiz 306. doi: 10.1055/s-0032-1313567. Epub 2012 May 24.
[Article in German]

Abstract

The use of muscle relaxants facilitates endotracheal intubation and ameliorates the conditions of surgery. But, their use should be controlled - otherwise there will be postoperative residual curarisation which can lead to patient discomfort up to severe medical complications. Therefore, an appropriate surveillance via objective neuromuscular monitoring is essential. This article gives a review of the basic principles of muscle relaxants, their clinical application and the surveillance of their effects and degradation.

Publication types

  • Review

MeSH terms

  • Anesthesia Recovery Period
  • Anesthesia*
  • Electric Stimulation
  • Humans
  • Intraoperative Period
  • Intubation, Intratracheal
  • Monitoring, Intraoperative / methods*
  • Muscle Relaxants, Central* / adverse effects
  • Muscle Relaxants, Central* / antagonists & inhibitors
  • Muscle, Skeletal / drug effects*
  • Nervous System Physiological Phenomena / drug effects*
  • Neuromuscular Depolarizing Agents / adverse effects
  • Neuromuscular Depolarizing Agents / antagonists & inhibitors
  • Neuromuscular Nondepolarizing Agents / adverse effects
  • Neuromuscular Nondepolarizing Agents / antagonists & inhibitors
  • Succinylcholine / adverse effects
  • Succinylcholine / antagonists & inhibitors
  • Sugammadex
  • gamma-Cyclodextrins / therapeutic use

Substances

  • Muscle Relaxants, Central
  • Neuromuscular Depolarizing Agents
  • Neuromuscular Nondepolarizing Agents
  • gamma-Cyclodextrins
  • Sugammadex
  • Succinylcholine