Tooth whitening with hydrogen/carbamide peroxides in association with a CPP-ACP paste at different proportions

Aust Dent J. 2012 Jun;57(2):213-9. doi: 10.1111/j.1834-7819.2012.01683.x. Epub 2012 Apr 4.

Abstract

Background: Different enhanced peroxide formulations have been developed to overcome mineral loss during tooth whitening. This study investigated the impact on tooth whitening from combining a CPP-ACP paste with home peroxide agents at several proportions.

Methods: Ninety bovine incisors were randomly allocated into nine groups (n = 10) and exposed to 7.5% hydrogen peroxide (HP), 16% carbamide peroxide (CP), a CPP-ACP paste (Tooth Mousse/MI Paste, GC Corporation, Tokyo, Japan) and blends of HP/CP:MI at three proportions (1:1, 2:1 and 1:2). Tooth whitening was performed for 14 days and its effectiveness was measured by a spectrophotometer utilizing the CIE L*a*b* system (ΔE, ΔL*, Δa* and Δb*). Colour readings were measured at baseline (T0), 7 days of bleaching (T7), 14 days of bleaching (T14) and 7 days after the end of bleaching (T21). Data were analysed by two-way ANOVA for paired averages followed by the Tukey's test and Pearson's correlation at 5%.

Results: Although CP produced the greatest colour change (ΔE), all whitening protocols were considered to be effective regardless of the CPP-ACP presence. In general, greater changes in ΔE, ΔL*, Δa* and Δb* were detected at T14, with T21 exhibiting similar results to those at T7. A greater number of strong correlations with ΔE values was found for a* (11/15).

Conclusions: Within the limitations of this study, the results indicate that the CPP-ACP paste did not affect tooth whitening efficacy.

MeSH terms

  • Animals
  • Carbamide Peroxide
  • Caseins / pharmacology*
  • Cattle
  • Colorimetry
  • Dentin / drug effects
  • Drug Antagonism
  • Drug Combinations
  • Hydrogen Peroxide / administration & dosage
  • Peroxides / administration & dosage
  • Spectrophotometry
  • Tooth Bleaching / methods*
  • Tooth Bleaching Agents / administration & dosage*
  • Urea / administration & dosage
  • Urea / analogs & derivatives

Substances

  • Caseins
  • Drug Combinations
  • Peroxides
  • Tooth Bleaching Agents
  • casein phosphopeptide-amorphous calcium phosphate nanocomplex
  • Carbamide Peroxide
  • Urea
  • Hydrogen Peroxide