Molecular characterisation of sinonasal carcinomas and their clinical implications

Abstract

Sinonasal carcinomas are rare tumours with an unfavourable prognosis whose management is difficult and complex, leading to high morbidity and mortality despite improvements in the field of surgery and radiotherapy. An elevated number of these tumours can be attributed to occupational exposure. In comparison with other head and neck malignancies, studies of molecular changes in these tumours are infrequent. This review was focused on findings about the epidemiology and molecular and phenotypic characterisation of sinonasal carcinomas, which can potentially be useful for diagnosis and treatment. The increasing knowledge about the molecular biology that underlies their carcinogenesis may help to identify precursor lesions, prognostic markers and markers that predict chemoradiotherapy response and, finally, to identify potential molecular targets that will expand treatment options.

Keywords: Adenocarcinomas; Carcinomas epidermoides; Carcinomas nasosinusales; Genetic profile; Marcadores moleculares; Molecular markers; Perfil genético; Sinonasal carcinomas; Squamous cell carcinomas.