Immunogenicity and safety of measles-mumps-rubella and varicella vaccines coadministered with a fourth dose of Haemophilus influenzae type b and Neisseria meningitidis serogroups C and Y-tetanus toxoid conjugate vaccine in toddlers: a pooled analysis of randomized trials

Kristina Bryant; Jodie McVernon; Colin Marchant; Terry Nolan; Gary Marshall; Peter Richmond; Helen Marshall; Michael Nissen; Stephen Lambert; Emmanuel Aris; Narcisa Mesaros; Jacqueline Miller

doi:10.4161/hv.20357

Immunogenicity and safety of measles-mumps-rubella and varicella vaccines coadministered with a fourth dose of Haemophilus influenzae type b and Neisseria meningitidis serogroups C and Y-tetanus toxoid conjugate vaccine in toddlers: a pooled analysis of randomized trials

Hum Vaccin Immunother. 2012 Aug;8(8):1036-41. doi: 10.4161/hv.20357. Epub 2012 Aug 1.

Authors

Kristina Bryant¹, Jodie McVernon, Colin Marchant, Terry Nolan, Gary Marshall, Peter Richmond, Helen Marshall, Michael Nissen, Stephen Lambert, Emmanuel Aris, Narcisa Mesaros, Jacqueline Miller

Affiliation

¹ University of Louisville, Louisville, KT USA. k0brya01@louisville.edu

Abstract

A pooled analysis was conducted of 1257 toddlers who received a fourth dose of Haemophilus influenzae type b-Neisseria meningitidis serogroups C and Y-tetanus toxoid conjugate vaccine (HibMenCY-TT) or Hib conjugate vaccine (Hib polysaccharide conjugated to N. meningitidis outer membrane protein) coadministered with measles-mumps-rubella (MMR) and varicella (VAR) vaccines (NCT00134719/NCT00289783). Noninferiority of immunological responses to MMR and VAR was demonstrated between groups and incidences of MMR- and VAR-specific solicited symptoms were similar, indicating that HibMenCY-TT can be coadministered with MMR and VAR.

Publication types

Meta-Analysis
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

MeSH terms

Chickenpox Vaccine / administration & dosage
Chickenpox Vaccine / adverse effects*
Chickenpox Vaccine / immunology*
Female
Haemophilus Vaccines / administration & dosage
Haemophilus Vaccines / adverse effects*
Haemophilus Vaccines / immunology*
Humans
Infant
Male
Measles-Mumps-Rubella Vaccine / administration & dosage
Measles-Mumps-Rubella Vaccine / adverse effects*
Measles-Mumps-Rubella Vaccine / immunology*
Randomized Controlled Trials as Topic
Tetanus Toxoid / administration & dosage
Tetanus Toxoid / adverse effects*
Tetanus Toxoid / immunology*
Vaccines, Conjugate / administration & dosage
Vaccines, Conjugate / adverse effects
Vaccines, Conjugate / immunology

Substances

Chickenpox Vaccine
Haemophilus Vaccines
Hib-MenCY-TT vaccine
Measles-Mumps-Rubella Vaccine
Tetanus Toxoid
Vaccines, Conjugate

Associated data

ClinicalTrials.gov/NCT00134719
ClinicalTrials.gov/NCT00289783