An ultrasensitive electrochemical impedance sensor for a special BRCA1 breast cancer gene sequence based on lambda exonuclease assisted target recycling amplification

Huifeng Xu; Lili Wang; Hongzhi Ye; Lishuang Yu; Xi Zhu; Zhenyu Lin; Guangwen Wu; Xihai Li; Xianxiang Liu; Guonan Chen

doi:10.1039/c2cc31588b

An ultrasensitive electrochemical impedance sensor for a special BRCA1 breast cancer gene sequence based on lambda exonuclease assisted target recycling amplification

Chem Commun (Camb). 2012 May 22. doi: 10.1039/c2cc31588b. Online ahead of print.

Authors

Huifeng Xu¹, Lili Wang, Hongzhi Ye, Lishuang Yu, Xi Zhu, Zhenyu Lin, Guangwen Wu, Xihai Li, Xianxiang Liu, Guonan Chen

Affiliation

¹ Academy of Integrative Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian, P. R. China. liuxianxiang@163.com.

PMID: 22617257
DOI: 10.1039/c2cc31588b

Abstract

A label-free, target recycling electrochemical impedance spectroscopy (EIS) DNA sensor has been developed for detection of a model related to the BRCA1 breast cancer gene with a detection limit of 0.05 nM.