Abstract
A silver triflate and palladium acetate co-catalyzed reaction of N'-(2-alkynylbenzylidene)hydrazide with N-allyl ynamide is described, which generates 2-amino-H-pyrazolo[5,1-a]isoquinolines in good to excellent yield. The transformation proceeds with high efficiency through 6-endo cyclization, [3 + 2] cycloaddition, 3,3-sigmatropic rearrangement, and aromatization.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alkynes / chemistry*
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Amides / chemistry*
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Catalysis
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Combinatorial Chemistry Techniques
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Cyclization
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Hydrazines / chemistry*
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Isoquinolines / chemical synthesis*
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Isoquinolines / chemistry
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Mesylates / chemistry*
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Molecular Structure
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Palladium / chemistry*
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Silver / chemistry*
Substances
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Alkynes
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Amides
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Hydrazines
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Isoquinolines
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Mesylates
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Silver
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Palladium
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trifluoromethanesulfonic acid