Treatment of refractory intracranial hypertension with 23.4% saline in children with severe traumatic brain injury

Kazuma Nakagawa; Cherylee W J Chang; Matthew A Koenig; Mihae Yu; Sheri Tokumaru

doi:10.1016/j.jclinane.2011.10.011

Treatment of refractory intracranial hypertension with 23.4% saline in children with severe traumatic brain injury

J Clin Anesth. 2012 Jun;24(4):318-23. doi: 10.1016/j.jclinane.2011.10.011.

Authors

Kazuma Nakagawa¹, Cherylee W J Chang, Matthew A Koenig, Mihae Yu, Sheri Tokumaru

Affiliation

¹ Neuroscience Institute, The Queen's Medical Center, Honolulu, HI 96813, USA. kazuma.nakagawa@hawaii.edu

PMID: 22608588
DOI: 10.1016/j.jclinane.2011.10.011

Abstract

The safety and efficacy of osmotic therapy with mannitol and 3% saline in the pediatric head-injured population has been widely reported; the use of 23.4% saline in children for the treatment of refractory intracranial hypertension has not. The clinical and physiologic responses of multiple 23.4% saline boluses in two children with severe traumatic brain injury (TBI) are presented. No complications were associated with the use of 23.4% saline in either patient.

Publication types

Case Reports
Research Support, Non-U.S. Gov't

MeSH terms

Brain / diagnostic imaging
Brain Injuries / complications*
Brain Injuries / diagnostic imaging
Brain Injuries / physiopathology
Child, Preschool
Female
Fluid Therapy / methods
Humans
Infant
Intracranial Hypertension / diagnostic imaging
Intracranial Hypertension / etiology*
Intracranial Hypertension / physiopathology
Intracranial Hypertension / therapy*
Intracranial Pressure / physiology
Male
Saline Solution, Hypertonic / therapeutic use*
Tomography, X-Ray Computed

Substances

Saline Solution, Hypertonic