mTHPC--a drug on its way from second to third generation photosensitizer?

Mathias O Senge

doi:10.1016/j.pdpdt.2011.10.001

mTHPC--a drug on its way from second to third generation photosensitizer?

Photodiagnosis Photodyn Ther. 2012 Jun;9(2):170-9. doi: 10.1016/j.pdpdt.2011.10.001. Epub 2011 Nov 1.

Author

Mathias O Senge¹

Affiliation

¹ Medicinal Chemistry, Institute of Molecular Medicine, Trinity Centre for Health Sciences, Trinity College Dublin, St James's Hospital, Dublin 8, Ireland. sengem@tcd.ie

PMID: 22594988
DOI: 10.1016/j.pdpdt.2011.10.001

Abstract

5,10,15,20-Tetrakis(3-hydroxyphenyl)chlorin (mTHPC, Temoporfin) is a widely investigated second generation photosensitizer. Its initial use in solution form (Foscan®) is now complemented by nanoformulations (Fospeg®, Foslip®) and new chemical derivatives related to the basic hydroxyphenylporphyrin framework. Advances in formulation, chemical modifications and targeting strategies open the way for third generation photosensitizers and give an illustrative example for the developmental process of new photoactive drugs.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Humans
Mesoporphyrins / therapeutic use*
Neoplasms / drug therapy*
Photochemotherapy / methods*
Photochemotherapy / trends*
Photosensitizing Agents / therapeutic use

Substances

Mesoporphyrins
Photosensitizing Agents
temoporfin