Involvement of corticospinal tract in Wilson's disease. A study of three cases with transcranial stimulation

Mov Disord. 1990;5(4):334-7. doi: 10.1002/mds.870050416.

Abstract

Muscle responses evoked by transcranial stimulation were studied in three patients with Wilson's disease. Abnormalities indicating involvement of corticospinal tract were demonstrated in one patient. In keeping with recent evoked potential studies, this finding suggests that lesions in Wilson's disease may affect structures other than the extrapyramidal system.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Electric Stimulation
  • Female
  • Hepatolenticular Degeneration / drug therapy
  • Hepatolenticular Degeneration / physiopathology*
  • Humans
  • Male
  • Muscle Contraction / physiology
  • Muscles / innervation*
  • Penicillamine / administration & dosage
  • Pyramidal Tracts / physiopathology*
  • Reaction Time / physiology
  • Trientine / administration & dosage

Substances

  • Penicillamine
  • Trientine