Abstract
Diabetes mellitus type 1 provokes the development of the oxidative stress, accompanied by the increased level of TBA-active products, activation of NO-synthases and increased production of nitric oxide. Activation of glutathione reductase, decrease of the glutathione peroxidase and superoxide dismutases activity was observed. This shows a specific disturbance in the functioning of the antioxidant defense system and the augmentation in the concentration of one of the major first line reacting cytokin (IL-1beta).
MeSH terms
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Adult
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Antioxidants / metabolism*
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Diabetes Mellitus, Type 1 / blood*
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Diabetes Mellitus, Type 1 / physiopathology
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Female
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Glutathione Peroxidase / blood
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Glutathione Reductase / blood
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Humans
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Interleukin-1beta / blood
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Male
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Nitric Oxide / biosynthesis
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Nitric Oxide Synthase Type II / blood
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Oxidative Stress
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Superoxide Dismutase / blood
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Thiobarbiturates / analysis
Substances
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Antioxidants
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Interleukin-1beta
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Thiobarbiturates
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Nitric Oxide
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Glutathione Peroxidase
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NOS2 protein, human
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Nitric Oxide Synthase Type II
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Superoxide Dismutase
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Glutathione Reductase
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thiobarbituric acid