Trends in antihypertensives use among Moroccan patients

Pharmacoepidemiol Drug Saf. 2012 Oct;21(10):1067-73. doi: 10.1002/pds.3288. Epub 2012 May 14.

Abstract

Purpose: In this study, we analyzed the consumption trends of antihypertensives in Morocco during the 1991-2010 period and the impacts after the institution of Mandatory Health Insurance and the marketing of generic drugs.

Methods: We used sales data from the Moroccan subsidiary of IMS Health "Intercontinental Marketing Service". The consumption volumes were converted into defined daily doses (DDDs).

Results: Between 1991 and 2010, outpatient consumption of antihypertensives went from 4.37 to 23.14 DDD/1000 inhabitants/day, a 5.30-fold increase. In 2010, calcium channel blockers (CCBs) and angiotensin converting enzyme inhibitors (ACEI) were the most consumed (4.97 DDD/1000 inhabitants/day) for each one, followed by diuretics (4.20 DDD/1000 inhabitants/day). The most consumed products were amlodipine (4.27 DDD/1000 inhabitants/day) followed by ramipril (3.18 DDD/1000 inhabitants /day) and indapamide (1.72 DDD/1000inhabitants/day). Between 1991 and 2010, the consumption of generic antihypertensives went from 2% to 46%.

Conclusion: Antihypertensive consumption increased between 1991 and 2010. However, despite the increase of generic drugs consumption, the levels of antihypertensive consumption remain lower than the needs of hypertensive patients.

MeSH terms

  • Antihypertensive Agents / therapeutic use*
  • Drug Utilization / statistics & numerical data
  • Drug Utilization / trends*
  • Drugs, Generic / therapeutic use
  • Humans
  • Hypertension / drug therapy*
  • Insurance, Health / statistics & numerical data
  • Insurance, Health / trends
  • Morocco

Substances

  • Antihypertensive Agents
  • Drugs, Generic