Abstract
Solasodine acetate, an anticancer steroidal alkaloid, was synthesized from diosgenin in 8 steps with an overall yield of 23%. A key synthetic step involves the formation of 5/6-oxazaspiroketal moiety via hypoiodite-mediated aminyl radical cyclization of a steroidal primary amine.
Copyright © 2012 Elsevier Inc. All rights reserved.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Amines / chemistry
-
Antineoplastic Agents / chemical synthesis*
-
Diosgenin / chemistry
-
Free Radicals / chemistry
-
Humans
-
Iodine Compounds / chemistry
-
Solanaceous Alkaloids / chemical synthesis*
-
Steroids / chemical synthesis*
Substances
-
Amines
-
Antineoplastic Agents
-
Free Radicals
-
Iodine Compounds
-
Solanaceous Alkaloids
-
Steroids
-
hypoiodous acid
-
Diosgenin
-
solasodine