Abstract
Jomthonic acid A (1), a new modified amino acid, was isolated from the culture broth of a soil-derived actinomycete of the genus Streptomyces. The structure and absolute configuration of 1 were determined by spectroscopic analyses and chemical conversion. Jomthonic acid A (1) induced differentiation of preadipocytes into mature adipocytes at 2-50 μM.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adipocytes / drug effects*
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Adipocytes / metabolism
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Amino Acids / chemistry
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Amino Acids / isolation & purification*
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Amino Acids / metabolism
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Molecular Structure
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Nuclear Magnetic Resonance, Biomolecular
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Soil Microbiology*
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Streptomyces / chemistry*
Substances
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Amino Acids
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jomthonic acid