Sigpep: calculating unique peptide signature transition sets in a complete proteome background

Proteomics. 2012 Apr;12(8):1142-6. doi: 10.1002/pmic.201100566.

Abstract

We have created a new software platform called sigpep that analyzes transition redundancy in selected reaction monitoring assays. Building on this platform, we also created a web application to generate transition sets with unique signatures for targeted peptides. The platform has been made available under the permissive Apache 2.0 open-source license, and the web application can be accessed from http://iomics.ugent.be/sigpep.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Humans
  • Internet
  • Mass Spectrometry / methods*
  • Molecular Sequence Data
  • Peptides / analysis*
  • Proteome / analysis*
  • Proteomics / methods*
  • Reference Standards
  • Software*
  • Trypsin / chemistry

Substances

  • Peptides
  • Proteome
  • Trypsin