Mechanistic insight into pentatricopeptide repeat proteins as sequence-specific RNA-binding proteins for organellar RNAs in plants

Plant Cell Physiol. 2012 Jul;53(7):1171-9. doi: 10.1093/pcp/pcs069. Epub 2012 May 9.

Abstract

The pentatricopeptide repeat (PPR) protein family is highly expanded in terrestrial plants. Arabidopsis contains 450 PPR genes, which represents 2% of the total protein-coding genes. PPR proteins are eukaryote-specific RNA-binding proteins implicated in multiple aspects of RNA metabolism of organellar genes. Most PPR proteins affect a single or small subset of gene(s), acting in a gene-specific manner. Studies over the last 10 years have revealed the significance of this protein family in coordinated gene expression in different compartments: the nucleus, chloroplast and mitochondrion. Here, we summarize recent studies addressing the mechanistic aspect of PPR proteins.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Amino Acid Motifs
  • Amino Acid Substitution
  • Arabidopsis / genetics
  • Arabidopsis / metabolism*
  • Arabidopsis Proteins / genetics
  • Arabidopsis Proteins / metabolism*
  • Chloroplasts / genetics
  • Chloroplasts / metabolism
  • Gene Expression Regulation, Plant
  • Genes, Plant
  • Mitochondria / genetics
  • Mitochondria / metabolism
  • RNA / genetics
  • RNA / metabolism*
  • RNA Editing
  • RNA, Mitochondrial
  • RNA, Plant / genetics
  • RNA, Plant / metabolism*
  • RNA-Binding Proteins / genetics
  • RNA-Binding Proteins / metabolism*
  • Species Specificity

Substances

  • Arabidopsis Proteins
  • RNA, Mitochondrial
  • RNA, Plant
  • RNA-Binding Proteins
  • pentatricopeptide repeat protein, Arabidopsis
  • RNA