Abstract
SMAD transcription factors are key mediators of the transforming growth factor-beta (TGFß) family of cytokines. Reversible phosphorylation of SMAD proteins plays a key role in regulating their function. Several phosphatases have been proposed to act on SMAD proteins to influence TGFß/BMP signalling. Here we provide an overview of the SMAD regulation by different protein phosphatases and review the evidence supporting each phosphatase as a candidate SMAD-phosphatase.
Copyright © 2012 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Bone Morphogenetic Proteins / metabolism
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Drosophila
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Humans
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Models, Biological
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Phosphoprotein Phosphatases / metabolism
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Phosphoric Monoester Hydrolases / metabolism*
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Phosphorylation
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Phosphotransferases / metabolism
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Protein Phosphatase 2C
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Protein Structure, Tertiary
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Signal Transduction
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Smad Proteins / metabolism*
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Transforming Growth Factor beta / metabolism
Substances
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Bone Morphogenetic Proteins
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Smad Proteins
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Transforming Growth Factor beta
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Phosphotransferases
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Phosphoprotein Phosphatases
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Protein Phosphatase 2C
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Phosphoric Monoester Hydrolases