Phosphatases in SMAD regulation

FEBS Lett. 2012 Jul 4;586(14):1897-905. doi: 10.1016/j.febslet.2012.02.001. Epub 2012 Feb 11.

Abstract

SMAD transcription factors are key mediators of the transforming growth factor-beta (TGFß) family of cytokines. Reversible phosphorylation of SMAD proteins plays a key role in regulating their function. Several phosphatases have been proposed to act on SMAD proteins to influence TGFß/BMP signalling. Here we provide an overview of the SMAD regulation by different protein phosphatases and review the evidence supporting each phosphatase as a candidate SMAD-phosphatase.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Bone Morphogenetic Proteins / metabolism
  • Drosophila
  • Humans
  • Models, Biological
  • Phosphoprotein Phosphatases / metabolism
  • Phosphoric Monoester Hydrolases / metabolism*
  • Phosphorylation
  • Phosphotransferases / metabolism
  • Protein Phosphatase 2C
  • Protein Structure, Tertiary
  • Signal Transduction
  • Smad Proteins / metabolism*
  • Transforming Growth Factor beta / metabolism

Substances

  • Bone Morphogenetic Proteins
  • Smad Proteins
  • Transforming Growth Factor beta
  • Phosphotransferases
  • Phosphoprotein Phosphatases
  • Protein Phosphatase 2C
  • Phosphoric Monoester Hydrolases