Abstract
Here we report a novel method for the manipulation and concentration of Aβ amyloid fibrils, implicated in Alzheimer's disease, using DC insulating gradient dielectrophoresis (DC-iGDEP). Fibril enrichment was found to be ∼400%. Simulations suggest that capture of the full range of amyloid protein aggregates is possible with optimized device design.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Amyloid beta-Peptides / chemistry*
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Amyloid beta-Peptides / isolation & purification*
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Electric Conductivity*
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Electric Impedance
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Electrophoresis / methods*
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Protein Multimerization*
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Protein Structure, Secondary