Abstract
Novel thiazolidinedione derivatives were synthesized by incorporating pharmacologically significant heterocycles viz, substituted thiazole, triazole, and oxadiazole moieties linked to the central phenyl ring via heteroatomlinkage with one/two carbon spacer as the structural analogs of Pioglitazone by employing multistep synthetic protocols. Structures of all the newly synthesized intermediates and target molecules were established by analytical and spectral data. These newly synthesized compounds were screened for their invivo hypoglycemic and hypolipidemic activities in male wistar rats. Some of the synthesized compounds demonstrated good activity.
Copyright © 2012 Elsevier Masson SAS. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Chemistry Techniques, Synthetic
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Diabetes Mellitus, Experimental / drug therapy
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Hypoglycemic Agents / chemical synthesis
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Hypoglycemic Agents / chemistry
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Hypoglycemic Agents / pharmacology
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Hypoglycemic Agents / therapeutic use
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Hypolipidemic Agents / chemical synthesis
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Hypolipidemic Agents / chemistry
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Hypolipidemic Agents / pharmacology
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Hypolipidemic Agents / therapeutic use
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Male
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Oxadiazoles / chemistry*
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Rats
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Rats, Wistar
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Thiazoles / chemistry*
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Thiazolidinediones / chemical synthesis*
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Thiazolidinediones / chemistry
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Thiazolidinediones / pharmacology*
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Thiazolidinediones / therapeutic use
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Triazoles / chemistry*
Substances
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Hypoglycemic Agents
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Hypolipidemic Agents
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Oxadiazoles
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Thiazoles
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Thiazolidinediones
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Triazoles
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2,4-thiazolidinedione