Trigoxyphins H and I: two new daphnane diterpenoids from Trigonostemon xyphophylloides

Biao Yang; Guang-Ying Chen; Xiao-Ping Song; Liu-Qing Yang; Chang-Ri Han; Xiang-Yang Wu; Xiao-Man Li; Bing-Yan Zou

doi:10.1016/j.bmcl.2012.03.069

Trigoxyphins H and I: two new daphnane diterpenoids from Trigonostemon xyphophylloides

Bioorg Med Chem Lett. 2012 Jun 1;22(11):3828-30. doi: 10.1016/j.bmcl.2012.03.069. Epub 2012 Mar 24.

Authors

Biao Yang¹, Guang-Ying Chen, Xiao-Ping Song, Liu-Qing Yang, Chang-Ri Han, Xiang-Yang Wu, Xiao-Man Li, Bing-Yan Zou

Affiliation

¹ Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, Hainan Normal University, Haikou 571158, PR China.

PMID: 22572582
DOI: 10.1016/j.bmcl.2012.03.069

Abstract

Two new daphnane diterpenoids (1 and 2), together with four known analogues (3-6) were isolated from Trigonostemon xyphophylloides. Their structures were elucidated by spectroscopic analysis. Compounds 1 and 2 were evaluated for in vitro cytotoxic activities against the SPCA-1 (human lung cancer) and BEL-7402 (human hepatocellular carcinoma) cancer cell lines. Trigoxyphin I (2) showed modest cytotoxicity against two tumor cell lines.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antineoplastic Agents, Phytogenic / chemistry*
Antineoplastic Agents, Phytogenic / isolation & purification
Antineoplastic Agents, Phytogenic / toxicity
Apoptosis / drug effects
Cell Line, Tumor
Diterpenes / chemistry*
Diterpenes / isolation & purification
Diterpenes / toxicity
Euphorbiaceae / chemistry*
Humans
Magnetic Resonance Spectroscopy
Molecular Conformation

Substances

Antineoplastic Agents, Phytogenic
Diterpenes
trigoxyphin H
trigoxyphin I