Complete genome sequence of an overattenuated highly pathogenic porcine reproductive and respiratory syndrome virus

J Virol. 2012 Jun;86(11):6381-2. doi: 10.1128/JVI.00710-12.

Abstract

JXA1-P170 is an overattenuated highly pathogenic porcine reproductive and respiratory syndrome virus (HP-PRRSV) that has been passaged in vitro 170 times. Vaccination with JXA1-P170 cannot protect pigs against JXA1 challenge. Compared with the parental virus JXA1, JXA1-P170 contains 1 nucleotide (nt) deletion and 113 nt mutations leading to 59 amino acid substitutions. Here we announce the first complete genome sequence of the overattenuated HP-PRRSV.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Genome, Viral*
  • Molecular Sequence Data
  • Mutation, Missense
  • Point Mutation
  • Porcine respiratory and reproductive syndrome virus / genetics*
  • Porcine respiratory and reproductive syndrome virus / growth & development
  • Porcine respiratory and reproductive syndrome virus / pathogenicity*
  • RNA, Viral / genetics*
  • Sequence Analysis, DNA*
  • Sequence Deletion
  • Serial Passage
  • Swine
  • Virulence

Substances

  • RNA, Viral

Associated data

  • GENBANK/JQ804986