Protein-carbon nanotube sensors: single platform integrated micro clinical lab for monitoring blood analytes

Abstract

Design of a unique, single-platform, integrated, multichannel sensor based on carbon nanotube (CNT)-protein adducts specific to each one of the major analytes of blood, glucose, cholesterol, triglyceride, and Hb1AC is presented. The concept underlying the sensor, amperometric detection, is applicable to various disease-monitoring strategies. There is an urgent need to enhance the sensitivity of glucometers to <5% level instead of greater than the present 15% standard in these detectors. CNTs enhance the signals derived from the interaction of the enzymes with the different analytes in blood. Fabricated sensors using the new methodology is a point-of-care device that is targeted for home, clinical, and emergency use and can be redesigned for continuous monitoring for critical care patients.